Mechanism of Metabolic Abnormality of Thyroid Hormones in Walker 256 Carcinosarcoma-bearing Rats
نویسندگان
چکیده
منابع مشابه
[Decreased hydroxylation of steroid hormones by liver microsomes from rats bearing Walker carcinosarcoma 256].
The hydroxylating activities of liver microsomes for proges terone and testosterone were markedly decreased in male and female rats bearing Walker carcinosarcoma 256. The decreases in the hydroxylating activities were greater in the male rats than in the female rats. The content of cytochrome P-450 in liver microsomes was decreased in the tumor-bearing male and female rats. Moreover, the bindin...
متن کاملPhysiological disposition of 1-acetyl-2-picolinoylhydrazine (NSC68626) in rats bearing Walker carcinosarcoma 256.
The purpose of the study was to investigate distribution and metabolism of l-acetyl-2-picolinoylhydrazine in tissues of tumor-bearing rats in order to understand the basis of its toxicity and antitumor activity. Drug labeled with 14Cin the carbonyl moiety was used to determine drug-derived radio activity. A procedure involving chloroform extraction and paper chromatography was used to determine...
متن کاملImpairment of feeding response to cold exposure of rats bearing Walker 256 carcinosarcoma.
The feeding response to cold exposure of male Sprague-Dawley rats bearing Walker 256 carcinosarcoma has been measured at 5 degrees, 13 degrees, and 17 degrees exposure. The cold-specific feeding response of the host is estimated taking account of the food cost of the tumor and of changes in food intake induced by weight change of host produced by both cold exposure and tumor growth. The cold-sp...
متن کاملPlasma and brain amino acids in Walker 256 carcinosarcoma-bearing rats.
that amino acids from tumor protein breakdown may be used as precursors for the synthesis of new protein in tumor cells. Tumor cells have the ability to concentrate amino acids from the plasma amino acid pool more efficiently than do normal cells, thus enabling them to compete successfully with the tissues of their host for available amino acids (17). During times of reduced dietary intake, res...
متن کاملDNA polymerases of Walker 256 carcinosarcoma.
Walker 256 carcinosarcoma in rats has been a useful tu mor for the evaluation of potential chemotherapeutic agents. Recently, several compounds with proven antiviral activity were also shown to inhibit the growth of Walker 256 carcinosarcoma, suggesting the possibility that an oncogenic virus, through a mechanism such as recruitment, for example, might be an essential factor for the growth of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1991
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1991.tb01752.x